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RNA medicines for vascular rejuvenation

Reversing Vascular Aging with RNA Therapeutics

Cardivia Labs is pioneering RNA-based medicines to reverse vascular aging and treat atherosclerosis. We aim to restore vascular health, extend cardiovascular healthspan, and transform outcomes for millions at risk of heart attack and stroke.

View Pipeline How it works
Cardivia Labs Overview
Science

RNA therapeutics engineered for the vasculature

Vascular aging is not inevitable. By targeting the genetic drivers of vascular decline, we are unlocking a future where cardiovascular disease is preventable and reversible. Our precision RNA therapeutics reprogram vascular biology and restore youth-like function.

  • Target-Site Blockers (TSBs) — Disarm microRNA repression at target mRNA sites to increase protective gene expression.
  • Antisense Oligonucleotides (ASOs) — Selectively silence pathogenic transcripts that drive inflammation and plaque growth.

These therapies selectively modulate protective and pathogenic gene pathways involved in vascular regeneration, lipid handling, inflammation, and vascular cell health.

Platform Strengths

  • Proprietary miRNA-targeting strategy
  • Cell-specific vascular targeting
  • Validated gene targets with strong biology
  • Scalable across cardiovascular indications
  • Designed for lipid- and nanoparticle-based delivery
Mechanism of Action

Reprogramming endothelial & smooth muscle cells

  • Enhances expression of protective longevity genes in ECs & VSMCs (e.g., SIRT6, TET2, CXCR4)
  • Silences inflammatory and atherogenic mediators within the vascular wall (e.g., CXCR2)
  • Strengthens endothelial barrier function and vascular repair capacity
  • Promotes vascular stability and resilience against age-related injury
Mechanism Illustration
Pipeline

First-in-class RNA programs for vascular rejuvenation

Program Modality Target Primary Cell Type Indication Stage
CXCR4-TSB TSB CXCR4 Endothelium & VSMC Atherosclerosis IND-enabling (upcoming)
SIRT6-TBS TSB SIRT6 Endothelium & VSMC Vascular Aging Preclinical
TET2-TBS TSB+AAV TET2+OSK Endothelium & VSMC Vascular Rejuvenation Discovery
CXCR2-ASO ASO CXCR2 Vascular Wall Plaque Stability Discovery
Team

Leadership & Advisors

Ismail Cimen, PhD

Founder & CEO

Scientist-founder translating cell-targeted RNA therapeutics for vascular rejuvenation and atherosclerosis. Leads strategy, platform development, and partnerships to advance TSB/ASO programs toward IND-enabling studies.

Berk Avcı

Chief Financial Officer

Financial leadership for Cardivia’s growth and clinical translation—planning, fundraising, and capital strategy to support RNA therapeutic development.

Headquarters

Rochester, NY, USA
Get in touch

Advisors

  • Prof. Dan Peer — Scientific Advisor (RNA delivery)
  • Prof. Craig Morrell — Scientific Advisor (Cardiovascular Biology)

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Contact

Partner with Cardivia Labs

For collaborations, business development, and investor inquiries:

info@cardivialabs.com

Headquartered in Rochester, NY, USA

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RNA medicines for vascular rejuvenation
RNA medicines for vascular rejuvenation
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